Thomson Reuters have reported known issues with the current version of Endnote X7 and the newest version of macOS Sierra (10.12).
The first one affects the version of Endnote available to download and use on your own computer from the Flinders website. The installers for Endnote that allow us to set up a download with Flinders licensing are unable to be installed with the license key on macOS Sierra. This will not be resolved until Thomson Reuters release version X8 of Endnote.
The second affects Endnote on both personal and Flinders PCs. An issue with the PDF viewer, means that annotating PDFs needs to be done in an external application.
If you use Endnote, it is recommended to wait to upgrade to macOS Sierra until Endnote X8 is released.
More information can be found in the Endnote knowledgebase here: http://endnote.com/kb/140624